Significant Advance in Treatment of Breast Cancer Reported:small study of chemo+tipif
http://www.docguide.com/news/content...2571A70060A8E6
Significant Advance in Treatment of Breast Cancer Reported NEW YORK, N.Y. -- July 10, 2006 -- In what may be a significant advance for the treatment of breast cancer, researchers at Montefiore Medical Center and the Moffitt Cancer Center and Research Institute have discovered they can more effectively wipe out diseased tissue when standard chemotherapy is combined with a drug that shuts down certain molecular pathways involved in causing cancer. In a multicenter clinical trial reported in the July, 2006 issue of the [Journal of Clinical Oncology, women with locally advanced breast cancer were given an oral medication that inhibits an enzyme called farnesyltransferase, in addition to routine chemotherapy, before undergoing surgery. Farnesyltransferase is required to set in motion a series of molecular events involved in the development of cancer
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This is so interesting because.... it is contray to all conventional wisdom in treating cancer, other than possibly herceptin. Shutting-off a growth factor / receptor pathway as stated in the article is would be not unlike giving aromitase inhibitors during chemo... maybe they should start thinking about multiple pathway inhibition, cox2, E, VEGF, P53, EGFR, etc. during chemo.....
Just a thought Al |
COX2, VGEF, P53 and the growth factors have all been reported by various trial in varying degrees as being "inhibited" by omega three (and by impilication reduction in omega six).
Thought provoking adjuvant potential in addition to any other treatment chosen. Interestingly several trials of chemo agents show that omega 3s had a synergysitic effect, and for some of them surprising high figures were quoted. RB |
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