Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effe
 

1: Cancer Lett. 2009 Jun 18;278(2):174-82. Epub 2009 Feb 8.http://www.ncbi.nlm.nih.gov/corehtml...PubMedLink.gif <script language="JavaScript1.2"><!-- var Menu19203831 = [ ["UseLocalConfig", "jsmenu3Config", "", ""], ["Substance (MeSH Keyword)" , "window.top.location='/sites/entrez?Db=pcsubstance&DbFrom=pubmed&Cmd=Link&LinkN ame=pubmed_pcsubstance_mesh&LinkReadableName=Subst ance%20(MeSH%20Keyword)&IdsFromResult=19203831&ord inalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubme d_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbst ractPlus' ", "", ""], ["LinkOut", "window.top.location='/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=1920 3831&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubm ed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubme d_RVAbstractPlus' ", "", ""] ] --></script>Links
<dd class="abstract">
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.

<!--AuthorList-->Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH.
Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong, Puk-ku, Gwangju, Republic of Korea.
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.
</dd> Mechanism of Action Compounds isolated from Cinnamon mimicked the action of insulin by activating the insulin receptors (17). Cinnamon has been demonstrated to inhibit hepatic HMG-CoA reductase activity and reduce levels of blood lipids in animals and humans; however evidence is conflicting as it has also been shown to raise cholesterol levels in rats (11). Hydroxycinnamaldehyde, a compound present in cinnamon, exhibits anti-inflammatory activity by inhibiting nitric oxide production via inhibition of NF-kappaB (4). top Contraindications # Patients taking blood glucose lowering or blood-thinning medications should use cinnamon extract with caution (4). # Cinnamon was shown to have estrogenic activity in vitro (19). Patients with hormone sensitive disease should use caution.


Cancer Lett. 2009 Jun 18;278(2):174-82. Epub 2009 Feb 8.
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.

Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH.
Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong, Puk-ku, Gwangju, Republic of Korea.
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.

PMID: 19203831 [PubMed - indexed for MEDLINE]