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-   -   Ganetespib For Metastatic HER2+ or Triple Negative Disease (http://her2support.org/vbulletin/showthread.php?t=59116)

'lizbeth 09-25-2013 11:57 AM

Ganetespib For Metastatic HER2+ or Triple Negative Disease
 
Ganetespib For Metastatic HER2+ or Triple Negative Disease

An Open Label Multicenter Phase 2 Window of Opportunity Study Evaluating Ganetespib(STA-9090) Monotherapy in Women With Previously Untreated Metastatic HER2 Positive or Triple Negative Breast Cancer (9090-11)
Summary

Ganetespib (STA-9090) is an investigational drug. It is an Hsp90 inhibitor: It works by blocking Hsp90 (heat shock protein 90), a molecular chaperone that plays a role in cell signaling. Hsp90 has been studied in previous trials that have enrolled patients with HER2-positive tumors. It may also be an effective way to treat triple negative (ER-,PR- and HER2-) breast cancer. The purpose of this study is to determine if ganetespib is effective in the treatment of patients with HER2+ or triple negative breast cancer who have not received prior systemic treatment for metastatic disease.hibition may be an important new approach to treating triple negative breast cancer.
This is a Phase II trial


http://clinicaltrials.gov/show/NCT01677455


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