Over come resistance to Neratinib with Affinitor.
Given that Neratinib has been out not that long ago, and already resistance to it has developed as in
Neratinib resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4. https://www.ncbi.nlm.nih.gov/pubmed/28152547 The below news is welcome. Essentially Neratinib and Affinitor could overcome this resistance. Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers https://www.sciencedirect.com/scienc...835?via%3Dihub |
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