Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

A highly thought provoking new fluoride alert video.

As previously stated fluoride is a naturally occurring substance which likely has roles in the body even if we are as yet unclear exactly what they are, (and the same goes for rare elements such as arsenic, which is commonly known to be highly toxic, but none the less in the tiny amounts to which we are usually exposed may have roles in cellular function). Fluoride clearly causes medical problems in inappropriate quantities, and but in appropriate amounts when applied direct to teeth has been shown to increase enamel hardness.

The problem is in the modern world we are at risk of having too much fluoride in our dietary / water/ tooth product / medical / airborne sources, and as a population are largely unaware of the dangers it poses in excess.

The situation is further complicated by the fact we are often deficient in other minerals, the level of ingestion of fluoride depends on the food source it is found in and the other minerals therein, and we are putting large amounts of fluoride into the environment which we ingest through air water and the food chain, all of which begs the question is the fluoridation of water still appropriate.



http://fluoridealert.org/fan-tv/10-facts/

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

A highly thought provoking video lecture by Jorge Flechas - he is clearly impassioned to communicate his experience using iodine with patients - it is sad there is not more research into the issues raised . . . as regularly observed there is great debate about what constitutes the optimal intake band of iodine either for repairing deficiency or ongoing maintenance. There is significant evidence that the Japanese have a much higher intake than those in the west; from 1mg a day up depending which source is examined - how much higher is debated - clearly there must be papers that support the higher intake figures in pregnancy but as yet I have not managed to find them - I will try harder :)


http://www.youtube.com/watch?v=uc4Q3kzBSc4#t=1865

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

^ This is a 2011 study

Iodine status of pregnant and postpartum Japanese women: effect of iodine intake on maternal and neonatal thyroid function in an iodine-sufficient area.

http://jcem.endojournals.org/content/96/12/3846.long

Based on the secretion of iodine in urine there seems to be a wide variation of intakes in pregnant women from insufficient to probably quite high. There is no suggestion that higher intakes were harmful, but equally the subject is not discussed,beyond reference to one or two figures.

Modern intakes may not be representative of historic intakes, and it will a long time before we know what is happening to the incidence of cancer etc.

ABSTRACT

"The rates of the pregnant and postpartum women who excreted iodine less than 100 μg/liter (0.79 μmol/liter) were 16.1% (110 of 684 women) and 35.7% (190 of 532 women), respectively (P < 0.0001). High iodine excretion greater than 500 μg/liter (4.0 μmol/liter) was found in 22.2% (152 of 684) of pregnant women and 14.1% (75 of 532) of postpartum women (P = 0.0003). Extremely high UI values exceeding 1000 μg/liter (7.9 μmol/liter) were found in 13.5% (92 of 684) of pregnant women and 6.6% (35 of 532) of postpartum women (P < 0.0001)."

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

http://jcem.endojournals.org/content/94/5/1683.long

Title
Thyroid function in early pregnancy in Japanese healthy women: relation to urinary iodine excretion, emesis, and fetal and child development.

Journal
Journal of Clinical Endocrinology & Metabolism 2009 Vol. 94 No. 5 pp. 1683-1688

Abstract

Context: The effect of constant rich iodine intake, especially during pregnancy, has not been well understood. Objective: The objective was to examine urinary iodine excretion and thyroid function in early pregnancy in Japanese healthy women. We also studied fetal maturation and child development in these women. Design and Setting: This study was an observational, prospective study conducted at a maternity hospital. Subjects: Subjects were 622 pregnant women who visited a maternity hospital consecutively in early gestation. Subjects with positive thyroid antibodies were excluded, and finally 514 subjects were examined. Offspring subjects were infants born to the maternal subjects. Main Outcome Measures: Thyroid function, serum thyroperoxidase antibodies, and urinary concentrations of iodine were measured at the initial obstetrical visit. The fetal maturation scores estimated by the Dubowitz and Ballard methods in newly born infants were assessed. A child developmental test was performed using the Enjoji Scale up to 12 months of age. Results: The distribution of urinary iodine concentrations was large, and the average was extremely high. There were significant positive correlations between urinary iodine and serum TSH (r=0.1326; P<0.005). Serum TSH during early pregnancy in mothers had no relevance to parameters in neonates, scores of fetal maturation, or child developmental testing in their infants. Conclusions: Iodine excess during early pregnancy seems to have no adverse effects on the fetus in healthy Japanese women. To avoid hypothyroidism, reducing excess dietary iodine intake to moderate intake may be beneficial for pregnant woman in Japan.


The official Japanese recommendation appears to be 3mg; the chart of urinary iodine shows intakes ranged widely and some were very high.

"Considering all the various factors together, the limit of iodine intake for healthy Japanese pregnant women should be around 3000 μg iodine/d, as recommended by the Japanese Health, Labor and Welfare Ministry (9)."

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

The above paper begs the question how well does iodine intake and urinary iodine correlate. This paper goes some way to confirming in general terms a strong correlation.

http://www.ymj.kr/Synapse/Data/PDFDa...ymj-39-355.pdf

Clearly the difficulties in assessing iodine intake because of the large variations due to processing and food preparation are significant.

But based on this paper it can be reasonably assumed that high urinary outputs do correlate with high intakes, so based on urinary iodine output cited in the papers above we can be certain that some Japanese do indeed consume significant amounts of iodine; further generally there is no indication that this intake has negative health consequences.

Of course nothing is ever simple, so higher urinary outputs for a given intake in some could be due to other factors including differences in transporter function, historic intake and so levels of tissue saturation including fat and muscle, absence of intake of iodine uptake blockers in so far as they can affect net uptake through the gut iodine transporters, other dietary differences such as polyunsaturated fat intake etc. It appears much is still unknown.

However overall if you have not at some point ingested the iodine it is not possible to excrete it, so it is inescapable that on a population basis higher excretion must point to higher intake.

I would find it surprising if nobody has looked at uptake and excretion in population groups known to have a high long term intake of iodine, but have not come across any such papers so far.

In the table in this paper the UK and USA have the lowest intakes, indeed the UK ranks towards the bottom of a global ranking of iodine intakes; no 7 in a list of "The top 10 iodine-deficient countries (based on national median UIC <100 μg/L) with the greatest numbers of SAC with insufficient iodine intake in 2011. SAC, school-age children; UIC, urinary iodine concentration." Fig 3 http://nutrition.highwire.org/content/142/4/744.full

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Whilst looking for something on a totally different biological topic I came across these two blogs by an MD / radiologist on iodine and breast cancer.

The first http://jeffreydachmd.com/breast-canc...n-with-iodine/ is interesting because it points out;

"Potassium iodide has been prescribed safely to large numbers pulmonary (COPD) patients in amounts of up to 6 grams per day for several years. This is a well known treatment for chronic obstructiove pulmonary disease (COPD) which helps mobilize lung secretions. (18)"

Please NOTE the above amount is in GRAMS, US recommendations are in micrograms (one millionth of a gram) and Japanese recommendations in milligrams on thousandth of a gram - So 6 grams is a lot in terms of current dietary recommendation; 2000 times the Japanese recommendation of 3mg - yes this was /is? being used as a medicine and is not the sort of amount any Doctor I have seen is recommending as a normal dietary intake. It would be fascinating to know what side effects have been observed in what percentage of patients etc.

and also says

"The FDA has officially stated that Iodine supplementation is safe and actually recommends 165 mg of Iodine for adults in case of Radiation Emergency to protect the population from thyroid cancer. (17)"






The second http://jeffreydachmd.com/iodine-treats-breast-cancer/ is interesting for its extensive list of references set out in a clear format, along with some case histories report by Dr Brownstein in his book which were either not in the earlier version or I had forgotten about them .

"
Iodine Treats Breast Cancer, Overwhelming Evidence by Jeffrey Dach MD
Arrow points to Breast Cancer on PET SCAN

Arrow points to Breast Cancer on PET SCAN

Iodine Treats Breast Cancer, the Overwhelming Evidence

by Jeffrey Dach MD

This article is Part Two of a series. For Part One , Click Here.

Spontaneous Regression of Breast Cancer

David Brownstein MD reports three cases of spontaneous regression of breast cancer after women take iodine supplementation.(1) (This is reported on page 63 of the Iodine Book by David Brownstein MD.)

Joan, an English Teacher

The first patient, Joan a 63 year old English teacher, was diagnosed with breast cancer in 1989, declined conventional treatment, and took 50 mg per day of Iodoral, (Iodine). Six weeks later, a PET scan (left image) showed, “all of the existing tumors were disintegrating”. Upper Left Image: Upper two frames is a PET scan showing breast cancer )(red arrows). Lower two frames is a CAT scan showing enhancing breast cancer mass, red arrow. Courtesy of Wikimedia Commons.

Delores

The second patient, 73 year old Delores, was diagnosed with breast cancer in 2003. She declined conventional treatment with radiation and chemotherapy. Instead, Dolores took 50 mg of Iodoral daily. A follow up ultrasound of the breast 18 months later showed,” It appears that these malignancies have diminished in size since the last examination. Interval improvement is definitely seen,” Two years later a follow up mammogram and ultrasound failed to show any abnormality and were read by the radiologist as normal.

Joyce

The third patient, 52 year old Joyce was diagnosed with breast cancer two years prior (left image), and started on Iodoral 50 mg per day. Three years after starting Iodoral, her follow up mammograms and ultrasound exams show decreasing size of the tumor with no progression.(1) . . .


MORE FOLLOWS http://jeffreydachmd.com/iodine-treats-breast-cancer/

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Another accidental find, not what I was searching for but is fascinating.

If you open this link http://books.google.com/books?id=7v7...ontent&f=false
it will take you to a page of a book called the Iodine Hand Book.

The graph graphically shows the effect of food based iodine blockers on the uptake of iodine by the thyroid; the effect is significant !

Earlier graphs in the pages above the one referred to show that the body maintains fairly stable levels of T4 in-spite of the presence of food based iodine blockers where iodine is adequate.

Another graph shows the effect of iodine intake an blockers on thyroid size.

The relative distribution of iodine between organs and tissue in the body is presumably dependent on iodine intake. I postulate if intake is low most iodine will be found in the thyroid, but when iodine intake is high most will be found mainly other tissues. This would explain the different figures that are given as to the distribution of iodine in the body. The gender of the test animal will also logically have a bearing on the results.

It appears the body is protective of the iodine status of the thyroid, and the focus on it to the exclusion of other iodine research is distorting our views and knowledge on wider iodine metabolism.

The atomic and molecular properties of iodine, its size, potential to bond in many different ways, and odd snippets of research suggest we have hardly even begun to understand the wide roles of iodine in the body.

http://books.google.com/books?id=7v7...ontent&f=false

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

I do not have access to the full papers but from a wider perspective this is intriguing.

Firstly those with cystic fibrosis may commonly be iodine deficient, presumably due to uptake issues. http://www.ncbi.nlm.nih.gov/pubmed/23107148(Low selenium may be an issue too it has been suggested - selenium is important to the metabolism of iodine)

and in 1956 an salivary iodine based test was proposed for cystic fibrosis of the pancreas.

All of which raises all sorts of questions and possibilities, and particularly so given iodine's association with the mucal membranes /systems / sweating etc

A SCREENING TEST FOR CYSTIC FIBROSIS OF THE PANCREAS USING ANALYSIS OF SALIVA

Wayne Hart,
Mansour J. Naime

+ Author Affiliations

Children's Mercy Hospital, Kansas City, Missouri
The Department of Pediatrics, University of Kansas School of Medicine

Abstract

A screening test for cystic fibrosis of the pancreas utilizing analysis of saliva for iodine after oral administration of Lipiodol® is presented. Tables provide the results obtained from testing 11 children who have cystic fibrosis of the pancreas and 30 children who have no evidence of this disease. It is indicated that the test can be easily and rapidly performed.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Essence = adequate selenium is very important if you are eating iodine rich foods viz kelp or using iodine supplementation.

This is a bit nerdy but hopefully the detail below will help with the gist; don't worry I do not understand all of it either (-:

This paper looks at the effects of higher iodine intakes on the thyroid and the response of the thyroid which includes the productions of selenium related antioxidants.

The graphs plotting the action of the iodine importer shows it reduces in activity, but interestingly does not 'shut down' totally. http://mend.endojournals.org/content...expansion.html

Similarly T3 and T4 fall but do not 'shut down'. http://mend.endojournals.org/content...expansion.html

This leaves me wondering how accurate the common descriptions of the Wolff-Chaikoff as a 'shut down' effect are, or if something different to what is observed in this paper happens at much higher intakes.

The idea of a healthy normal thyroid that efficiently and rapidly adapts its intake to the amount of iodine in the system has a ring of natures common sense about it - is this what this data and the Wolff-Chiakoff data suggests? - the data above raises the question was the choice of the description 'shut down' used for the sometimes rapid auto-regulation of iodine uptake / fall in hormone production by the thyroid an unfortunate one because it implied a reaction that was more dramatic than that observed viz rapid auto-regulation ? - hopefully there will be more research to answer these questions . . .

Also can extra thyroidal iodine when present in high amounts for example as iodine attached to lipids etc, and or extra-thyrodial production of related hormones for example from the ovaries in any way partially compensate for lower T3 and T4?

Much science has to discover yet methinks, and within the known sea of knowledge I am still not yet a toddler.

The paper is available in full - I hope that applies to you to

Regulation of Thyroid Oxidative State by Thioredoxin Reductase Has a Crucial Role in Thyroid Responses to Iodide Excess

Suzana G. Leoni,
Edna T. Kimura,
Pilar Santisteban and
Antonio De la Vieja

http://mend.endojournals.org/content/25/11/1924.long

"In summary, our results provide new information about the molecular events involved in thyroid autoregulation by high doses of I−. First, we determined that the rapid blockade of I− uptake in thyroid cells is not occurring in parallel to NIS mRNA and protein modulation and also that it is not caused by NIS internalization. These observations suggest an inactivation of NIS localized at the plasma membrane. Second, the incorporation of large amounts of I− increases ROS species in the thyroid cell above basal levels. As a consequence, the expression and activity of TxnRd selenoproteins increase to compensate oxidation and avoid cell toxicity. Thus, these selenoproteins participate in thyroid I− autoregulation by allowing the restoration of a normal thyroid cell oxidation state and NIS reexpression"

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Here is another paper looking at the Wolff-Chaikoff effect, here again after ingestion / injection of a large amount of iodine there is a large fall in uptake, and temporary drop in T3 and T4, (T3 then recovers, and T4 increases) a metabolic adjustment but hardly a thyroid 'shutdown' as often described, in the in the normal sense of the word 'shutdown'.


http://endo.endojournals.org/content...expansion.html

http://endo.endojournals.org/content/140/8/3404.long

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Hashimoto's

An interesting pair of posts on Paul Jaminet's site by a Hashimoto's patient which is well referenced and highlights the importance of selenium, possible benefits at least in some of iodine supplementation, and the fundamental importance of a balanced intake of both selenium and iodine to thyroid function.

http://perfecthealthdiet.com/2011/05...iditis-part-i/

http://perfecthealthdiet.com/2011/05...iditis-part-2/

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Hasimoto's

Multifactoral - As ever it is important to keep in mind that most medical conditions are likely to be mutli-factoral, and have multiple associations with increased risks of other medical conditons Eg Hashimotos patients may be at increased risk of Pagets bone disease, http://europepmc.org/articles/PMC188...00365-0047.pdf which common bone conditions is linked with low vitamin D, begging the question is there maybe a link between low vitamin D and Hashimoto's . . .


The association between severity of vitamin D deficiency and Hashimoto's thyroiditis.
Bozkurt NC, Karbek B, Ucan B, Sahin M, Cakal E, Ozbek M, Delibasi T.
Author information
Abstract
OBJECTIVE:

The relation between vitamin D and autoimmune disorders has long been investigated regarding the important roles of this hormone in immune regulation. We evaluated 25-hydroxyvitamin D (25OHD) status in subjects with Hashimoto's thyroiditis (HT) and healthy controls.
METHODS:

Group-1 included 180 euthyroid patients (123 females/57 males) with HT who were on a stable dose of L-thyroxine (LT). A total of 180 sex-, age-, and body mass index (BMI)-matched euthyroid subjects with newly diagnosed HT were considered as Group-2, and 180 healthy volunteers were enrolled as controls (Group-3). All 540 subjects underwent thyroid ultrasound and were evaluated for serum 25OHD, anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-TG) levels.
RESULTS:

Group-1 had the lowest 25OHD levels (11.4 ± 5.2 ng/mL) compared to newly diagnosed HT subjects (Group-2) (13.1 ± 5.9 ng/mL, P = .002) and to control subjects (15.4 ± 6.8 ng/mL, P<.001). Serum 25OHD levels directly correlated with thyroid volume (r = 0.145, P<.001) and inversely correlated with anti-TPO (r = -0.361, P<.001) and anti-TG levels (r = -0.335, P<.001). We determined that 48.3% of Group-1, 35% of Group-2, and 20.5% of controls had severe 25OHD deficiency (<10 ng/mL). Female chronic HT patients had the lowest serum 25OHD levels (10.3 ± 4.58 ng/mL), and male control subjects had the highest (19.3 ± 5.9 ng/mL, P<.001).
CONCLUSIONS:

We demonstrated that serum 25OHD levels of HT patients were significantly lower than controls, and 25OHD deficiency severity correlated with duration of HT, thyroid volume, and antibody levels. These findings may suggest a potential role of 25OHD in development of HT and/or its progression to hypothyroidism.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

More suggestions of connection between iodine breast health and estrogen metabolism; the paper also suggests that iodine may indirectly affect BRAC1 related metabolism . . . thought provoking stuff.

Interestingly breast health appears to be dependent at least in part on iodine rather than iodide and at least in part of the independent of supply of iodine by T3 and T4 indicating thyroid independent effects of iodine, in addition to possible as yet unidentified mechanisms



Iodine Alters Gene Expression in the MCF7 Breast Cancer Cell Line: Evidence for an Anti-Estrogen Effect of Iodine

Frederick R. Stoddard II,1,2 Ari D. Brooks,1 Bernard A. Eskin,3 and Gregg J. Johannes2
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2452979/

The protective effects of iodine on breast cancer have been postulated from epidemiologic evidence and described in animal models. The molecular mechanisms responsible have not been identified but laboratory evidence suggests that iodine may inhibit cancer promotion through modulation of the estrogen pathway. To elucidate the role of iodine in breast cancer, the effect of Lugol's iodine solution (5% I2, 10% KI) on gene expression was analyzed in the estrogen responsive MCF-7 breast cancer cell line. Microarray analysis identified 29 genes that were up-regulated and 14 genes that were down-regulated in response to iodine/iodide treatment. The altered genes included several involved in hormone metabolism as well as genes involved in the regulation of cell cycle progression, growth and differentiation. Quantitative RT-PCR confirmed the array data demonstrating that iodine/iodide treatment increased the mRNA levels of several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1) while decreasing the levels of the estrogen responsive genes TFF1 and WISP2. This report presents the results of the first gene array profiling of the response of a breast cancer cell line to iodine treatment. In addition to elucidating our understanding of the effects of iodine/iodide on breast cancer, this work suggests that iodine/iodide may be useful as an adjuvant therapy in the pharmacologic manipulation of the estrogen pathway in women with breast cancer.


The high rate of breast disease in women with thyroid abnormalities (both dietary and clinical) suggests a correlation between thyroid and breast physiology 1-3. In addition, women with breast cancer have larger thyroid volumes then controls 2. Multiple studies suggest that abnormalities in iodine metabolism are the likely link 4-7. Additionally, the impact of iodine therapy for the maintenance of healthy breast tissue has been reported in both animal 4-7 and clinical studies 8, 9 yet the mechanisms responsible remain unclear . . . http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2452979/ FREE FULL TEXT


Evidence indicates that the impact of iodine treatment on breast tissue is independent of thyroid function. For example, iodine deficient rats given the thyroid hormone thyroxine (T4) did not achieve reduced tumor growth following NMU treatment suggesting that the effect of iodine on tumor growth is independent of the thyroid gland or thyroid hormone 7. Additionally, Eskin et al and others have reported that administration of molecular iodine has a greater impact on tumor growth than the equivalent dose of iodide 5-9. Since the thyroid primarily utilizes iodide as opposed to iodine 5, this data supports the hypothesis that iodine is not acting through the thyroid.

In addition to differences in the metabolism of iodine, the mechanisms of iodine and iodide uptake appear to differ. While iodide uptake is essentially via the Sodium-Iodide Symporter (NIS) in the thyroid, data suggests that iodine uptake in the breast may be NIS-independent, possibly through a facilitated diffusion system 12. Together this data indicates that the effect of iodine on breast cancer progression is in part independent of thyroid function and suggests that iodine's protective effect on breast cancer progression is elicited through its direct interactions with breast cancer cells.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Saw this and thought it worthy of posting - beware of OTC "thyroid boosting" supplements:

http://well.blogs.nytimes.com/2014/0...ef=health&_r=0

Hopeful

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

This is a very useful examination of the Iodine issue on the Western Price site which contains some material I had not seen before.

http://www.westonaprice.org/metaboli...-iodine-debate

I found the reference to historic intakes in the USA of iodine particularly interesting " Thirty years ago, when iodine consumption was twice as high as it is now (480 mcg per day) one in twenty women developed breast cancer. Thirty years ago, consumption of iodized salt was higher than it is today; in addition a form of iodine was used as a dough conditioner in making bread, and each slice of bread contained 0.14 mg of iodine. In 1980, bread makers started using bromide as a conditioner instead, which competes with iodine for absorption into the thyroid gland and other tissues in the body. Iodine was also more widely used in the dairy industry as a teat cleaner thirty years ago than it is now. According to this argument, 15 percent of the U.S. adult female population suffers from moderate to severe iodine deficiency.1"

I would be really interested to know if they saw higher levels of hyperthyroidism, which is one of the regularly advanced arguments against increasing the current intake recommendations.

I had not really taken on board that in some countries salt was fluoridated for example it appears both Germany and Switzerland inter alia fluoridate salt

http://www.ncbi.nlm.nih.gov/pubmed/16156167
http://www.ncbi.nlm.nih.gov/pubmed/16156165

Is intake in those that eat a lot of salt maybe sufficient to affect thyroid function - is this a potential issue; I have no idea but maybe worthy of consideration.

As referenced above iodine in salt will sublime so and it appears that the amounts of iodine in table salt may vary considerably; but I suspect fluoride levels would remain more stable, so users could end up with most of the fluoride but not much of the iodine - as ever just more unanswered questions . . .

As pointed out by Sally Fallon matters of health and nutrition are rarely straight forward.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

http://www.vitamindwiki.com/Hashimot...ltiple+studies


Some great studies suggesting a link between low Vitamin D and an increased risk of Hasimotos


Relative Vitamin D Insufficiency in Hashimoto's Thyroiditis (2011)

"Conclusions: We showed that serum 25OHD levels of patients with HT were significantly lower than controls and severity of vitamin-D deficiency correlated with duration of HT, thyroid volume and antibody levels. These findings may suggest a potential role of 25OHD in development of Hashimoto's thyroiditis and/or its progression to hypothyroidism. "

Hashimoto's autoimmune thyroiditis and vitamin D deficiency. Current aspects. (Feb 2014)

Risk of Hashimoto's Thyroiditis reduced 19 percent for each 5 ng increase in vitamin D – March 2014

"Conclusions
Our study suggested that higher serum 25OHD levels was associated with decreased risk of HT so that each 5 ng/ml increase in the serum 25OHD levels results in 19 % decrease in odds of HT. "

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

^ and does vitamin D have a role in hyperthyroidism

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461753/

"We have reported significantly lower vitamin D levels in Indian patients with hyperthyroidism 2. In this study, 30 patients with thyrotoxicosis were studied for vitamin D status and bone mineral density (BMD). The mean 25 (OH) vitamin D levels in patient group were 15.3±7.1 ng/ml and 30 per cent of patients had severe vitamin D deficiency (<10 ng/ml). We have postulated hyperpigmentation of skin, malabsorption and increased vitamin D metabolism as possible mechanisms of vitamin D deficiency in hyperthyroidism3. Authors of the present study1 have not cited this important paper which was first reported study on this subject from India. Goswami et al4 have reported malabsorption in Indian patients with hyperthyroidism. According to this study significant number of patients (46%) with thyrotoxicosis in India had fat mal- absorption4. Absorption of fat soluble vitamins such as vitamin D is likely to be hindered in such a state. It is worthwhile to study correlation between steatorrhea and vitamin D status in these patients with thyrotoxicosis. "


http://press.endocrine.org/doi/abs/10.1210/en.2008-1191

Vitamin D Deficiency Modulates Graves’ Hyperthyroidism Induced in BALB/c Mice by Thyrotropin Receptor Immunization

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

In the UK the Government recently asked the body responsible for setting national nutritional standards called SACN to look at iodine intake. In their consequent position statement (linked below) SACN declined to look at maternal iodine intake due to a lack of 'robust' evidence. There is a huge amount of non randomized control evidence (RCTs) as to the importance of iodine in development, and RCTs to look at the neurological impact of iodine deficits in pregnancy can never happen due to ethical implications. The refusal of SACN to look at the issue begs the question who is responsible. I put the issues below in questions to a director of NICE and Health for England (HFE) (UK health regulatory agencies) and made this delegate submission at a recent forum held by an excellent organization called the Westminster Forums. http://www.westminsterforumprojects.co.uk/ (the size of allowed submissions is limited). Importantly there is growing evidence that nutrient deficiency in the first trimester may lead to irreversible sub-optimal brain formation, for example incomplete neuron migration. There is also some evidence that fundamental factors such as abstract thought, empathy, musicality and higher human function generally may be compromised, which factors help define our humanity. Motor and more basic function is less sensitive to degradation. In a resource pressured world higher human function arguably including empathy and abstract thought is of fundamental importantance to the avoidance of conflict.


SUBMISSION

Optimal neurological development including IQ is crucial to individuals, society, and nations. Cell development in common with all cellular function, indeed life itself, is nutrient dependent. Is Health for England (HFE) ultimately responsible for national dietary and consequent nutrient intake; if not who is?

SACN reports to HFE but appears to restrict considerations to specific nutrient issues where science is ‘robust’; who then is responsible for assessment of health risks relating to significant population insufficiencies, where ‘evidence’ of risk is ‘weak’ e.g. no RCTs, but the overview fairly compelling? Further who is tasked to design and implement corrective strategies for existing identified nutritional insufficiencies.

For example SACN’s ‘Position Statement’ on iodine intake during pregnancy stated “The Subgroup advised that without further evidence it would not be possible to carry out a robust review of the UK DRV ”; although it is widely accepted very low iodine causes cretinism, and significant if ‘non-robust’ evidence suggests mild to moderate iodine deficiency may, starting in the first trimester, incrementally increase risks of irreversible sub-optimal brain formation, lower IQ 5-10 points, impair abstract thought, and lower other life-chance related developmental outcomes. (Maternal thyroxin supplies early foetus needs. Hypothyroxinemia is commonly associated with low iodine.) Accumulating evidence indicates growing iodine insufficiencies in adolescent females and pregnant women . Low income arguably increases deficiency risks. Further, DHA , and vitamin D deficiencies inter alia, likely also incrementally irreversibly compromise brain structure and function; examples of insufficiency and its effects include:

• DHA – 500 mg daily after week 22 reduced low birth weight babies by 35%, and very early pre-term deliveries by 50% (par 2.32) 7
• Iodine – 85% of adolescent females in a Belfast sample (par 5.1.1) 7 and 61% of pregnant women were classed as iodine deficient (par 5.1.5.2) 7
• Vitamin D – 75-96% of pregnant women were vitamin D insufficient 12

Iodine and vitamin D insufficiencies present particular challenges; realistically population based intake normalisation is only achievable through fortification or supplementation:

• Vitamin D food sources are limited compared to sun exposure production, which in modern day life is limited. The problem is particularly acute in the dark skinned.
• Iodine is only found in significant amounts in marine and particularly estuarine foods including seaweeds. Dairy foods are the next best source, but primarily because of cattle supplementation rather than pasture content . Other food sources of iodine are limited. Use of iodised salt, and idophors as food-industry disinfectants are falling. Iodine is lost during food preparation and storage, complicating intake assessments. Significant amounts are lost during intensive exercise. Iodine is stored in fat, so likely a greater issue in the obese. Thyroid iodide uptake is inhibited by a wide range of increasingly common foods including brassicas, perchlorates, and competing halides (bromine and chlorine), which group can partially be mitigated by higher iodine intake. Other rising factors that decrease thyroid function include high fluoride, nitrates, PCBs, chlorination, lithium, smoking, and likely polyunsaturated fat imbalances and excesses.

DHA is also mainly found in marine food, but livestock DHA could be increased somewhat by appropriate intervention. Inattention to dietary needs of livestock leads to large falls in DHA content.

In summary evidence grows of UK population wide insufficiencies in fertile and pregnant females of inter alia Omega 3 DHA, vitamin D, and iodine. Realistically addressing increasing pre and post-natal neurodevelopmental national nutrient insufficiency risks of particular relevance to the disadvantaged, including crucially iodine, vitamin D, and DHA, in fertile and pregnant females, can only be achieved by food supplementation; this will require bringing together health agricultural and food sectors in a quest for optimal solutions; the question is by whom?


1. SACN position statement on iodine and health - February 2014 – par. 122 http://www.sacn.gov.uk/pdfs/sacn_pos...and_health.pdf
2. Comprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspects - Victor R. Preedy, Gerard N. Burrow, Ronald Ross Watson - Academic Press, 17 Mar 2009 - Medical - 1334 pages – in part on line - multiple references e.g - (FYO I purchased a copy and have read it twice from cover to cover)
http://books.google.com/books?id=7v7...gnancy&f=false
3. Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC) - Sarah C Bath PhD, Colin D Steer MSc, Prof Jean Golding FMedSci, Pauline Emmett PhD, Prof Margaret P Rayman DPhil, - The Lancet, Volume 382, Issue 9889, Pages 331 - 337, 27 July 2013 - http://www.thelancet.com/journals/la...436-5/abstract
4. Section IV - The Scientific Basis for the Elimination of Brain Damage due to Iodine Deficiency – F Delange and B S Hetzel - http://www.iccidd.org/cm_data/hetzel-e-section4.pdf
5. Mild iodine deficiency in pregnancy in Europe and its consequences for cognitive and psychomotor development of children: A review – Caroline Trumpff, Jean De Schepper, Jean Tafforeau, Herman Van Oyen,
Johan Vanderfaeillie, Stefanie Vandevijvere – J Trace Elem Med Biol (2013) - http://www.iccidd.org/cm_data/2013_T...evelopment.pdf
6. Chapter 20 - The Iodine Deficiency Disorders - Creswell J. Eastman, M.D Michael Zimmermann, M.D – Thyroid Disease Manager - http://www.thyroidmanager.org/chapte...ncy-disorders/
7. Benefits of Docosahexaenoic Acid, Folic Acid, Vitamin D and Iodine on Foetal and Infant Brain Development and Function Following Maternal Supplementation during Pregnancy and Lactation. - Nancy L. Morse - Nutrients. Jul 2012; 4(7): 799–840 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407995/
8. Recommendations; UK 150mcg; WHO 250mcg; American Paediatrics 220 - 290mcg, Japan 3000mcg.
9. Dietary (n-3) Fatty Acids and Brain Development – Sheila M. Innis - J. Nutr. April 2007 vol. 137 no. 4 855-859
http://jn.nutrition.org/content/137/4/855.full
10. Omega-3 Fatty Acid Deficiency in Infants before Birth Identified Using a Randomized Trial of Maternal DHA
Supplementation in Pregnancy - Kelly A. Mulder, D. Janette King, Sheila M. Innis - LoS ONE 9(1): e83764. doi:10.1371/journal.pone.0083764 - http://www.plosone.org/article/fetch...esentation=PDF
11. DHA Deficiency and Prefrontal Cortex Neuropathology in Recurrent Affective Disorders – Robert K McNamara - J Nutr. Apr 2010; 140(4): 864–868. - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838627/
12. Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study - Valerie A. Holmes, Maria S. Barnes, H. Denis Alexander, Peter McFaul and Julie M. W. Wallace - British Journal of Nutrition / Volume 102 / Issue 06 / September 2009, pp 876-881 http://journals.cambridge.org/action...07114509297236
13. Vitamin D deficiency in pregnancy - still a public health issue. - McAree T1, Jacobs B, Manickavasagar T, Sivalokanathan S, Brennan L, Bassett P, Rainbow S, Blair M.- Matern Child Nutr. 2013 Jan;9(1):23-30. doi: 10.1111/mcn.12014.- http://www.ncbi.nlm.nih.gov/pubmed/23230904
14. Vitamin D3 and brain development - D Eyles, J Brown, A Mackay-Sim, J McGrath, F Feron http://www.direct-ms.org/pdf/VitDGen...evelopment.pdf
15. Developmental vitamin D deficiency causes abnormal brain development. - Eyles DW, Feron F, Cui X, Kesby JP, Harms LH, Ko P, McGrath JJ, Burne TH. - Psychoneuroendocrinology. 2009 Dec; 34 Suppl 1:S247-57. doi: 10.1016/j.psyneuen.2009.04.015. - http://www.ncbi.nlm.nih.gov/pubmed/19500914
16. The geochemistry of iodine and its application to environmental strategies for reducing the risks from iodine deficiency disorders http://nora.nerc.ac.uk/10724/1/CR03057N.pdf
17. To refine and confirm the level of selenium and iodine supplementation for breeding ewes http://www.eblex.org.uk/wp/wp-conten...ort-190214.pdf
18. POLICY STATEMENT Iodine Deficiency, Pollutant Chemicals, and the Thyroid: New Information on an Old Problem – COUNCIL ON ENVIRONMENTAL HEALTH – American Academy of Pediatrics - DOI: 10.1542/peds.2014-0900 ; originally published online May 26, 2014; Pediatrics http://pediatrics.aappublications.or....full.pdf+html
19. http://her2support.org/vbulletin/showthread.php?t=53928 I am R.B.
20. Modern organic and broiler chickens sold for human consumption provide more energy from fat than protein. Wang Y, Lehane C, Ghebremeskel K, Crawford MA. - Public Health Nutr. 2010 Mar;13(3):400-8. doi: 10.1017/S1368980009991157. - http://www.ncbi.nlm.nih.gov/pubmed/19728900

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

The Deficiency of Iodine in Asia is not so much prominent, but in the West the percentage of Deficiency of Iodine is higher which is major factor causing diseases related Breast.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

More sources of flouride :( :( :( from Flouride Alert - I have copied and pasted some of the content below, but it is worth visiting the site - there is more mind numbing information on this page in relation to developmental issues - flouride can both be used to kill bugs on foods and fumigate warehouses to kill bugs in them - apparently in the US it is not obligatory to move food when fumigating warehouses which where relevant could result in very high fluoride loads in food twice a year! - so you really do not know what little extras you might be getting this Thanksgiving or Christmas :(

http://fluoridealert.org/issues/sources/f-pesticides/

Pesticides

Due to its high toxicity, fluoride has long been used as a pesticide. In the United States, there are currently two fluoride-based pesticides that are allowed to be sprayed on food. These are: cryolite and sulfuryl fluoride.

2) According to data from the USDA (2005), the average fluoride levels in grape products are as follows:

White grape juice = 2.13 ppm
White wine = 2.02 ppm
Red wine = 1.05 ppm
Raisins = 2.34 ppm

3) Many juice drinks that are not labeled as “grape juice” use grape juice as a filler ingredient. The use of cryolite thus contaminates many juices with fluoride.

4) Cryolite is also allowed to be added to the following products (although it is unclear how many producers actually do so, and what the resulting fluoride levels are):

Apricot, Broccoli, Brussels Sprout, Cabbage, Cauliflower, Citrus fruit, Collards, Eggplant, Kale, Kiwifruit, Kohlrabi, Lettuce, Melon, Nectarine, Peach, Pepper, Plum, Pumpkin, Squash (summer & winter), Tomato, and a number of Berries (Blackberry, Blueberry (huckleberry) Boysenberry, Cranberry, Dewberry, Loganberry, Raspberry, Strawberry, Youngberry).


Direct Fumigation of Food

6) The EPA also allows food processors to use sulfuryl fluoride as a direct fumigant of certain foods. This means that food processors can purposely spray sulfuryl fluoride directly onto certain foods.

7) Unlike structural fumigation (which takes place once or twice a year), direct fumigation is a routinely performed procedure. Thus, foods that can be directly fumigated with sulfuryl fluoride will consistently have elevated fluoride levels.

8) According to EPA’s estimates, some of the foods that will be most commonly fumigated are cocoa powder, dried beans, walnuts and dried fruits.

9) EPA estimates that, if the current regulations are not rescinded, 100% of cocoa powder, 100% of dried beans, 99% of walnuts, 69% of dried fruits, 10% of walnuts, 10% of tree nuts, and 3% of rice will be fumigated.

10) When fumigated the average fluoride levels in fumigated food is:

Brown rice = 12.5 ppm
Cocoa powder = 8.4 ppm
Almonds = 5.3 ppm
Tree nuts = 5.3 ppm
Dried beans = 4.5 ppm
White rice = 4.5 ppm
Walnuts = 2.4 ppm
Dried fruits = 1 ppm

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

And something I had not checked before - does fluoride cross the placenta - yes - http://www.ncbi.nlm.nih.gov/pubmed/2182701 - which has scary potential implications.

The implications would be greater in those who are at risk of iodine deficiency and insufficiency in pregnancy.

Might it affect fetal brain development either directly or by inhibition of thyroid function and so iodine metabolism - Fluoride Alert saved me the trouble of looking for data - based on fetal autopsies high fluoride intake is associated with serious developmental abnormalities :( :( :( .

Some abstracts from the link below which is well worth a visit - truly an I want to scream moment - if mitochondria do not work everything is affected.

This data was of course related to high flouride intake, but as already discussed the uptake of flouride is altered by many factors including the form in which it is ingested, wider mineral uptake and availability, so the questions as to whether those who have intakes from water, food, drugs, excessive toothpaste, low mineral and iodine intake and other risks that may be additive are at higher risk of non optimal fetal development is as yet unanswered.



http://fluoridealert.org/studies/brain05/



The human placenta does not prevent the passage of fluoride from a pregnant mother’s bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning.

As highlighted by the excerpts below, three Chinese studies have investigated fluoride’s effect on the fetal brain and each has found evidence of significant neurological damage, including neuronal degeneration and reduced levels of neurotransmitters such as norepinephrine. As noted by Yu (1996), “when norepinephrine levels drop the ability to maintain an appropriate state of activation in the central nervous system is weakened.” Studies of fluoride-treated animals have reported similar effects, including lower levels of norepinephrine. (Kaur 2009; Li 1994).

The following study involves the same fetal tissue that was examined in the Yu (1996) and Dong (1993) studies. Rather than investigating fluoride’s effect on the brain, however, this study examined fluoride’s effect on the ultrastructure of cells in several tissues in the body, including from the thyroid gland. As can be seen in the following description, the fetuses from the fluoride-exposed women were experiencing a systemic toxic effect.

Conclusions: Fluoride damage to cell structures was multifaceted. Cell membranes, mitochondria, rough endoplasmic reticulum, and nuclear membranes could all be damaged at the time of fluorosis.”


another study said

These changes indicate that fluoride can retard the growth and division of cells in the cerebral cortex. Fewer mitochondria, microtubules, and vesicles within the synapses could lead to fewer connections between neurons and abnormal synaptic function, influencing the intellectual development after birth. These questions await further research.”
SOURCE: Han H, et al. (1989). Effects of fluorine on the human fetus. Chinese Journal of Control of Endemic Diseases 4:136-138. [See study]

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Does the placenta reduce the passage of fluoride to the baby? It might this paper asked that question and observed lower fluoride concentrations of the fetus side of the placenta to the maternal side.

Could western diet alter placental function, permeability etc; I would be surprised if it did not.

So as ever things are rarely simple.

http://njirm.pbworks.com/f/3Role+of+...t+flurosis.pdf

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Nitrates in water and thyroid function. There are several papers suggesting that nitrate pollution of well water may affect thyroid function. This is the biggest effect I have seen. :( :( I do not have access to the full paper but the potential implications are depressing. :( :( :(

http://www.ncbi.nlm.nih.gov/pubmed/17447577

Arch Environ Occup Health. 2005 Nov-Dec;60(6):317-9.
Iodine status of children living in areas with high nitrate levels in water.
Gatseva PD1, Argirova MD.
Author information
Abstract

Several researchers have suggested a possible relationship between nitrate intake and the development of goiter in children. The present cross-sectional study included schoolchildren between the ages of 11 and 14 years from 2 villages in Bulgaria with high and low nitrate levels in drinking water. The comparison between the median urinary iodine levels of the total number of exposed (179.0 microg/l) and nonexposed (202.50 microg/l) children showed statistically significant differences. The relative risk for the children exposed to high nitrate levels in drinking water, expressed as the odds ratio, was 8.145 (95% confidence interval = 1.67-39.67). The authors considered this to be very significant. They found a statistically significant difference for the prevalence of goiter among the exposed and nonexposed children. The results of the study confirmed the role of high nitrate levels in drinking water as a health risk factor for thyroid dysfunction.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Sea vegetables are great for this. (If someone already mentioned this, I'm sorry. I looked back and didn't see it mentioned). There are so many varieties available that have different flavors - but if you want to start with something on the milder side, try arame. You can sprinkle it on salads, for starters. Also, you can make snack chips out of nori.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

If anybody is in the UK and interested I am speaking at a Royal Society of Medicine food section conference on hidden nutritional deficiencies in my new role as recently appointed Chair of the McCarrison Society, which is a venerable society with its own widely recognized Journal 'Nutrition and Health'.

The Society has a long illustrious history, but is in need of a bit of revamping including a new web site.

I will be looking in whistle-stop fashion at deficiencies in nutrients particularly Iodine, Vitamin D, minerals, and imbalances in Omega 3 and 6 set within the context of the shoreline diet which arguably provided the conditions for out existence.

I am hoping to make the McCarrison Society a forum to bring together the Food Agricultural and Health sectors to the same table, which they never are, to try and bring focus on deficiencies such as Vitamin D, Iodine and secure the implementation of strategies to address them.

This is the link to the conference.

http://www.rsm.ac.uk/events/fhf01

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

RB,

Thank you for all the time and effort you make to keep us up to date on the information available, and for your expertise in coordinating the possibility for interaction and discussion at such a level as this conference.

I do hope someone from this site will attend. Thanks for providing early notice here to make that possible.

AlaskaAngel

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

How time flies!

Just found this looking for something else.

This is an excellent paper on iodine selenium and breast cancer, which emphasizes the interconnected nature of selenium and iodine and need for adequate amounts of both.

It also considers the relevance of fibrocystic breast disease, and the relevance of iodine thereto.

It also links in thyroid function.

It also recognizes that iodine is transported by other mechanisms than thyroxine including attachment to fats.

It was written in 2000 and emphasizes the need for more research which is still required in 2016.

It is available in full for free as a PDF.

Hypothesis: Iodine, selenium and the development of breast cancer

http://www.iodineresearch.com/files/...ast_cancer.pdf

An abstract

"High-grade fibrocystic disease (i.e., ductal or lobular
hyperplasia, but especially atypical hyperplasia) is gen-
erally believed to be a precursor to ductal carcinoma
in situ (DCIS) and subsequent invasive/metastatic car-
cinoma. Other symptoms of benign breast disease,
including cyclical mastalgia [12] and apocrine cysts
[13], have also been associated with an increased breast
cancer risk. In the USA it has been estimated that 50±
90% of women experience Fibrocystic disease during
their lifetime [14, 15]; a rate so high that some have
suggested that this condition should no longer be
classiÆed as a disease [14, 15]. However, downgrading
the disease status simply due to prevalence estimations is
questionable when this condition, in populations at low
risk for breast cancer, is so much less common [16].
Gravelle et al. [17] found that healthy British women
had signiÆcantly less low-risk (low-density) and a
greater proportion of high-risk (high-density) breast
parenchymal patterns than Japanese women. Further-
more, immigration studies suggest that these breast
parenchymal patterns may be inØuenced by nongenetic
factors. For example, Sasamo et al . [18] found that the
prevalence of breast epithelial hyperplasia was similar
between Japanese women (18.4%) and Japanese issei
Hawaiians (immigrant generation) (14.5%), but signif-
icantly lower than nisei Hawaiians (second generation)
(51.4%)."

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

An old but thought provoking paper suggesting possibly that thyroid dysbiosis is a risk in breast cancer. The author makes the point that the number are small etc, but it is nonetheless thought provoking including the observation that apparently breast cancer was rare in those that were hyperthyroid.

Hypothyroidism is linked with a greater risk of breast cancer.

http://www.ncbi.nlm.nih.gov/pmc/arti...03628-0022.pdf

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

well, does anybody know that iodine allergy exists? I didn't..till I found I have it.
The iodine does not induce an allergic reaction, but getting inside the body or on the skin, a microelement enters into a special reaction, which produces a foreign protein to the organism, and the existence of this element causes the development of allergic symptoms.
http://stopallergyguide.com/iodine-allergy/ and now I don't know how to compensate for the iodine deficiency.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

This link http://www.dermnetnz.org/topics/iodine/
states,

"Iodine allergy

The term ‘iodine allergy’ is commonly used, but is actually a misnomer. Iodine is a trace element present throughout the body, and is essential for the production of thyroid hormones. It is not possible to have a true allergy to elemental iodine.

‘Iodine allergy’ usually refers to an allergic-type reaction to iodinated radiological contrast media or, less commonly, an allergic contact reaction to povidone-iodine (Betadine™) antiseptics."

which would make more sense to me than the link in the post above namely http://stopallergyguide.com/iodine-allergy/ It looks as if people are conflating reaction to medications, sea food etc, with the elemental iodine/iodide; they are not the same thing.



If anybody comes across a reaction to iodine so Lugols or similar can they please post the information.

Of course it is important to seek medical advice when looking at iodine intakes and always be sensible and mindful in all aspect of diet and supplementation.

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

An informative review on iodine and cancer.

"There is substantial evidence that iodine deficiency is a modifiable risk factor in cancers of the stomach and breast."

- See more at: http://www.naturalmedicinejournal.co....nSs0Wc0v.dpuf

"Abstract

Iodine is an essential element in human physiology. Its role in thyroid function is well known and heavily weighted in the literature. Its putative role as an anticarcinogenic agent is just beginning to be widely appreciated. The molecular effects of iodine as well as ongoing epidemiological evidence points to its probable role in prevention of cancers through its antioxidant, antiinflammatory, prodifferentiating, and proapoptotic effects. This is particularly evident with stomach and breast cancers but may be relevant for many other cancers that have yet to be substantially studied."

"Epidemiological evidence also suggests that thyroid disorders, particularly goiter, may be associated with breast cancer incidence and/or mortality.5–8 Other cancers associated with goitrogenic state include prostate cancer, endometrial, ovarian, colorectal, and thyroid cancer. It is not clear whether these associations are due to an underlying hypothyroid state, the presence of occult autoimmune processes, or iodine deficiency itself."

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Found whilst looking for something else - in this instance iodine in Japanese breast milk - as is often the case.

As often the case with issues where there is no significant financial incentive because you cannot patent something, on this occasion iodine, and it is cheap, more research is required.

The paper is not too 'technical'. I abstract bits below to give a flavor of the review.

Free Full paper
http://jeffreydachmd.com/wp-content/...ntrol-2000.pdf

"In this paper we have focused on deficient iodine and
selenium intake as risk factors for breast cancer;
however, these elements have also been implicated in
the development of other hormone-dependent diseases,
such as ovarian [5, 97], uterine [5, 97, 98] and prostatic
carcinoma [99, 100]. In view of the complementary
nature of these two nutrients, a re-evaluation of optimal
iodine and selenium intake may be required. In-depth
studies, examining a combined role for these elements in
the prevention and treatment of cancer and other
degenerative diseases, would be a step in the right
direction"

"In estradiol-treated rats, iodine deficency has been
shown to lead to pathological changes similar to those
seen in benign breast disease ± cystic changes, per-
iductal fibrosis and lobular hyperplasia [19, 20].
Conversely, dietary iodine reintroduction has been
shown to reverse these pathological changes [20].
Thus, iodine deficiency appears to enhance mammary-
tissue sensitivity to estrogen."

"As with prevention, a role for iodine in the treatment
of breast cancer awaits further study. Traditional
eastern Asian medicine has long used iodine-rich sea-
weeds as a cancer treatment to ``soften'' tumors and
``reduce'' nodulation [30, 31]. Recent work with animal
systems seems to support an antitumor e€ect for iodine"

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

A perspective from medically qualified 'nutritonalist' (more qualifications than I have) that is put in plain terms. I have not checked his CV, and would take a more nuanced perspective on the RDA. Also the ideal dose he proposes is open to question, but Japanese intakes are higher than those in the west. As above the fluoride debate is heated and complex. Excess oxidative stress is a magor issue and certainly it happens in different time scales that reflect cellular function and 'purpose', but from a quick skim I have reservations about the direction of what is proposed, and my comments and posting of this post, is very much restricted to the iodine page, as I do not have the time to read all the site, comment on it etc.

Sadly space for debate is needed as much about iodine remains to be researched and quantified.

The web page is none the less a succinct and useful summary of issues to consider and research, ideally at the same time as talking to your doctor.


IODINE, A CRITICAL NUTRIENT

http://www.drlwilson.com/ARTICLES/IODINE.htm

by Dr. Lawrence Wilson

"One of the most important and overlooked minerals today is iodine. Iodine is needed in the thyroid gland to produce thyroid hormones. However, iodine is also required for every tissue of the body!

It is called the endocrine mineral because it is important not only for the thyroid gland, but also for the adrenal glands, ovaries, breasts, prostate gland, and the entire hormone system of the body. "

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo
 

Is Iodine closely related with hyperthyriodism?

Re: Iodine deficiency ! - falling intakes - goitregens - competition bromine and fluo