Rich66
11-01-2009, 04:23 PM
*might not be compatible with chemo etc. (http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
(http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
(http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
(http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
Pomegranate fruit extract impairs invasion and motility in human breast cancer (http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
Integrative Cancer Therapies , 10/12/09
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Khan GN et al. – Inhibition of motility and invasion by PFEs, coincident with suppressed RhoC and RhoA protein expression, suggests a role for these defined extracts in lowering the metastatic potential of aggressive breast cancer species.
Methods
Investigated effect of novel, defined PFE consisting of both fermented juice and seed oil on NF-kB pathway, which is constitutively active in aggressive breast cancer cell lines
Effects of PFE on NF-kB—regulated cellular processes such as cell survival, proliferation, and invasion also examined
Results
Analytical characterization of bioactive components of PFE revealed active constituents, mainly ellagitannins and phenolic acids in aqueous PFE and conjugated octadecatrienoic acids in lipid PFE derived from seed
Aqueous PFE dose-dependently inhibited NF-kB—dependent reporter gene expression associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression
(http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
(http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
(http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
Pomegranate fruit extract impairs invasion and motility in human breast cancer (http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
Integrative Cancer Therapies , 10/12/09
http://www.mdlinx.com/images/n_print.gifPrint (http://www.mdlinx.com/hemeonclinx/news-article.cfm/2909969/?print=1)
http://www.mdlinx.com/images/n_email.gifEmail This Article (http://www.mdlinx.com/hemeonclinx/email_user_arts.cfm?article_id=2909969&rank=0)
http://www.mdlinx.com/images/n_save.gifSave in My Library (https://www.mdlinx.com/hemeonclinx/add_user_arts.cfm?spec_id=17&addart=2909969)
http://www.mdlinx.com/images/n_archive.gifFree Abstract (http://www.mdlinx.com/readArticle.cfm?art_id=2909969)
Khan GN et al. – Inhibition of motility and invasion by PFEs, coincident with suppressed RhoC and RhoA protein expression, suggests a role for these defined extracts in lowering the metastatic potential of aggressive breast cancer species.
Methods
Investigated effect of novel, defined PFE consisting of both fermented juice and seed oil on NF-kB pathway, which is constitutively active in aggressive breast cancer cell lines
Effects of PFE on NF-kB—regulated cellular processes such as cell survival, proliferation, and invasion also examined
Results
Analytical characterization of bioactive components of PFE revealed active constituents, mainly ellagitannins and phenolic acids in aqueous PFE and conjugated octadecatrienoic acids in lipid PFE derived from seed
Aqueous PFE dose-dependently inhibited NF-kB—dependent reporter gene expression associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression