Brain tumour gene link found

[News]

Cancer Research UK funded scientists have discovered a mutation in a DNA repair gene which may increase the risk of developing meningioma , a rare type of brain tumour , according to new research published in the latest edition of the Journal of the National Cancer Institute .

More... (http://www.news-medical.net/?id=35551)

[RobinP]

The gene found is BRIP1 is a faulty DNA repair gene assoc. with breast cancer and meningioma ...


The BRIP1 gene is involved in the repair of DNA double-strand breaks by ... a manner that depends on its association with BRCA1. Defects in BRIP1 are linked to breast cancer susceptibility (as well as Fanconi anemia), leading researchers to speculate that the reported association between breast cancer and meningioma risk may be due to similar defects in DNA repair genes rather than/in addition to the previously assumed shared hormonal risk factors (such as hormone replacement therapy). This group also reported a statistically significant association between four variants in the ATM gene, a member of the phosphatidylinositol-3 kinase family, PI-3k ( Her2+ activate the PI-3k pathway) known to be involved in homologous and non-homologous DNA break repair, and meningioma risk. Previous groups have also noted significant associations between ATM variants for meningioma as well as breast cancer [23 (https://link.springer.com/article/10.1007/s11060-010-0386-3#CR23), 61 (https://link.springer.com/article/10.1007/s11060-010-0386-3#CR61)]. These findings are again of interest in light of the associations between ionizing radiation and meningioma risk as well as between breast cancer and meningioma risk.
https://link.springer.com/article/10.1007/s11060-010-0386-3