for all those interested in Mediteranean diet (RB, included of course)

[Lani]

Clin Transl Oncol. 2008 Jan;10(1):30-4.
Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century?

Colomer R, Lupu R, Papadimitropoulou A, Vellón L, Vázquez-MartÃ*n A, Brunet J, Fernández-Gutiérrez A, Segura-Carretero A, Menéndez JA.
M.D. Anderson International Madrid, Madrid, Spain.
We are accumulating evidence to suggest that 17(th) century Renaissance foodways -largely based on the old "Mediterranean dietary traditions"- may provide new nutraceutical management strategies against HER2-positive breast cancer disease in the 21st century. Epidemiological and experimental studies begin to support the notion that "The Sacred Law of Salads" (i.e., "raw vegetables... plenty of generous (olive) oil") -originally proposed in 1614 by Giacomo Castelvetro in its book The Fruit, Herbs & Vegetables of Italy- might be considered the first (unintended) example of customised diets for breast cancer prevention based on individual genetic make-up (i.e., nutraceuticals against human breast carcinomas bearing HER2 oncogene amplification/overexpression). First, the so-called salad vegetables dietary pattern (i.e., a high consumption of raw vegetables and olive oil) appears to exert a protective effect mostly confined to the HER2-positive breast cancer subtype, with no significant influence on the occurrence of HER2-negative breast cancers. Second, all the main olive oil constituents (i.e., the omega-9 monounsaturated fatty acid oleic acid and polyphenolic compounds such as the secoiridoid oleuropein or the lignan 1-[+]-acetoxypinoresinol) dramatically reduce HER2 expression and specifically induce apoptotic cell death in cultured HER2- positive breast cancer cells, with marginal effects against HER2-negative cells. Third, an olive oil-rich diet negatively influences experimental mammary tumorigenesis in rats likewise decreasing HER2 expression levels. If early 1600s Castelvetro's salads can be used as dietary protocols capable to protecting women against biologically aggressive HER2-positive breast cancer subtypes is an intriguing prospect that warrants to be evaluated in human pilot studies in the future. Here, at least, we would like to recognise Giacomo Castelvetro as the father of modern nutritional genomics in oncology.
PMID: 18208790 [PubMed - in process]


Related Links
Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9).
[Curr Pharm Biotechnol. 2006]
HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail".
[Clin Transl Oncol. 2006]
Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells.
[BMC Cancer. 2007]
Mediterranean diet, olive oil and cancer.
[Clin Transl Oncol. 2006]
Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification.
[Ann Oncol. 2005]
» See all Related Articles...

[RhondaH]

Glad I get my 9-13 a day AND my tbs of olive oil;)

Rhonda

[R.B.]

Many thanks as usual for posting.

Very interesting.

I wonder if fish featured.

RB

[fullofbeans]

Very interesting indeed ..we knew about the olive oil benefits but never read about scientific pub about the possible benefit of raw veg based diet before. Lani, many thanks as always.

[jones7676]

Thanks Lani for your work.....very interesting. I also use olive oil at night as a facial moisturizer to add to absorption.

[Becky]

Remember the book that tells you what kind of diet to eat for your blood type - I am type A and I am supposed to benefit from a Mediterrean diet. I should have done it years and years ago. Glad I did once I got bc (switched before surgery). And drinking the evoo before Herceptin treatments too.

Thanks for the confirmations.

[EstherO]

Hi Becky - what is evoo? - I am new at this chats. I received Taxol with herceptin for the last months. Originally I was HER2 NEG but looked further and FISH showed BORDERLINE - due the fact that this is my 2 recurrence 1998/2001/2007 I decided to do herceptin due trial results. I just read that patients with so called neg HER2 herceptin may not do anything.
I too will go into med diet - I have been using olive oil all my life and recently started with omega 3 oils as well.

[Jean]

EVOO - is abreviated for Extra Virgin Olive Oil.

Welcome!
Jean

[goops]

What book is that?

Can any one recommend a good book on the Medit. diet?

I find this thread very interesting, I did a web search of Her-2 and Olive oil and found some interesting articles, I also found a thread from this board were they were discussing Olive oil in 2005:

http://her2support.org/vbulletin/showthread.php?t=19216

[R.B.]

This thread might be of interest.

It is primarily about omega threes and sixes and BC but include to dietary links and link on olive oil.

RB



http://www.her2support.org/vbulletin/showthread.php?t=24410&highlight=greek+diet

[R.B.]

I have posted this before.

It links the pluses of omega threes <img src="http://www.world-of-smilies.com/wos_engel/wos_engell4.gif" alt="Good vs Evil 2" /> and the negatives of omega six, with the Mediterranean diet and Omega nine.

RB


". iii) Considering our previous findings demonstrating the HER2 upregulatory actions of the omega-6 PUFA linolenic acid (LA; 18:2n-6) and the HER2 down-regulatory actions of the omega-3 PUFA docosahexaenoic acid (DHA; 22:6n-3) and of the omega-9 monounsaturated fatty acid oleic acid (OA; 18:1n-9), it is reasonable to suggest that a low omega-6/omega-3 PUFA ratio and elevated MUFA levels, the two prominent fat features of the Mediterranean diet, should be extremely efficient at blocking HER2 expression in breast cancer cells."





http://www.ncbi.nlm.nih.gov/pubmed/17134970?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsP anel.Pubmed_RVDocSum

HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail".
Menéndez JA, Vázquez-MartÃ*n A, Ropero S, Colomer R, Lupu R.

Fundació d'Investigació Biomédica de Girona Dr. Josep Trueta (IdIBGi), Girona, Catalonia. Spain. javiermenendez72@yahoo.com

[chicagoetc]

Someone had written a list of foods they were eating that reflect the references here to a healthier Mediteranean diet. I just can't find it now that I am looking for it. I am looking for a simple list of foods to eat/focus on (too much of anything is not good I know...but knowing what is good would be helpful). Melanie

[hutchibk]

Thanks Lani! My onc laughed at me (in a sweet way, he loves to make fun of me) when I told him a couple of years ago that I was drinking EVOO every morning (I take 2 tablespoons) - but now I will send him this to show him I am not the nut that he sometimes thinks I am...

[goops]

What is EVOO?

[Mgarr]

Extra Virgin Olive Oil