ER-/PR+ Tamoxifen effectiveness?

[SusanC]

Hi Ladies,
I am struggling with Tamoxifen. Joint swelling, weight gain etc..., I am ER- and PR+ (strongly). I have been searching for someone on the board with similar path. report. I have read that Tamoxifen is not as effective for PR+. Do any of you gals have any info or experience with this? I would like to get back to "normal" and stop taking meds. I just finished Herceptin last month. That feels good!
Any input/advice would be appreciated!
Thank you,
Susan C.

[Becky]

I have the opposite pathology (ER+/PR-) and Tamoxifen tends to work better if you are positive for both (and strongly positive). Since your situation is rarer than mine, I would discuss with your onc on the effectiveness of Tamoxifen in your situation or if Evista or Megace might be better. I will see if I have something to post in my virtual library on this. However, I would never stop taking the Tamoxifen without discussing with your onc and maybe even getting another opinion (medical opinion) of what you should do.

[SusanC]

Thank you Becky for your reply. Yesterday, was a rough day and I wanted to just stop everything and forget this all happened!! I was so strong all through treatment but now I feel so unsure of things. After reading Andie's post about "your thoughts" (of course, always knew that) it places everything in perspective.
Thanks,
Susan C