Lani
08-28-2007, 05:23 AM
FEBS Lett. 2007 Aug 17; [Epub ahead of print]
Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy.
Chuang TC, Liu JY, Lin CT, Tang YT, Yeh MH, Chang SC, Li JW, Kao MC.
Department of Chemistry, Tamkang University, Tamsui, Taiwan, ROC; Graduate Institute of Life Sciences, Tamkang University, Tamsui, Taiwan, ROC.
The up-regulation of HER2/neu is associated with human malignancies and is a useful target for developing anticancer drugs. Overexpression of human manganese superoxide dismutase (MnSOD) has been demonstrated to effectively suppress various carcinoma cells, including breast carcinomas, in vitro and in vivo. This study demonstrates that MnSOD effectively suppresses HER2/neu oncogene expression at the transcriptional level. Additionally, stable transfection was used and the MnSOD-transfected human breast cancer clones were found to be able to down-regulate the endogenous production of p185(HER2/neu). Furthermore, the MnSOD-overexpressing stable transfectants exhibited reduced soft-agarose colony-forming ability and metastatic properties, unlike control cell lines. These data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy.
PMID: 17719580 [PubMed - as supplied by publisher]
Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy.
Chuang TC, Liu JY, Lin CT, Tang YT, Yeh MH, Chang SC, Li JW, Kao MC.
Department of Chemistry, Tamkang University, Tamsui, Taiwan, ROC; Graduate Institute of Life Sciences, Tamkang University, Tamsui, Taiwan, ROC.
The up-regulation of HER2/neu is associated with human malignancies and is a useful target for developing anticancer drugs. Overexpression of human manganese superoxide dismutase (MnSOD) has been demonstrated to effectively suppress various carcinoma cells, including breast carcinomas, in vitro and in vivo. This study demonstrates that MnSOD effectively suppresses HER2/neu oncogene expression at the transcriptional level. Additionally, stable transfection was used and the MnSOD-transfected human breast cancer clones were found to be able to down-regulate the endogenous production of p185(HER2/neu). Furthermore, the MnSOD-overexpressing stable transfectants exhibited reduced soft-agarose colony-forming ability and metastatic properties, unlike control cell lines. These data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy.
PMID: 17719580 [PubMed - as supplied by publisher]