Zometa or Clodronate in low doses fight metastatic bone cancer from breast(mice test)

[heblaj01]

This is the first time that frequent low doses of bisphosphonates such as Zometa or Clodronate are shown to be active against metastatic bone cancer in animal studies. Higher doses had previously been known to reduce risk of metastases in humans & to possibly slow progression.
The new finding has some superficial similarity with the low dose metronomic regimen of some chemo drugs such as Cytoxan.
http://jnci.oxfordjournals.org/cgi/content/abstract/99/4/322
Antitumor Effects of Clinical Dosing Regimens of Bisphosphonates in Experimental Breast Cancer Bone Metastasis

[heblaj01]

An other potential use of Zometa to treat osteosarcomas in combination with chemo drugs such as paclitaxel, gemcitabine, doxorubicin http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17242698&query_hl=3target=
Combined effects of a third-generation bisphosphonate, zoledronic acid with other anticancer agents against murine osteosarcoma.