R.B.
07-25-2006, 03:38 PM
This is in cows but fro me fascinating none the less.
Any potential for experimentaion for breast regrowth ?
What are the impacts in terms of cancer mechanisms?
Any thoughts?
RB
http://jas.fass.org/cgi/content/full/81/suppl_3/18
Lactation persistency: Insights from mammary cell proliferation studies
A. V. Capuco*,1, S. E. Ellis§, S. A. Hale¶, E. Long{dagger}, R. A. Erdman¶, X. Zhao# and M. J. Paape
ABSTRACT
"Evidence for the existence of mammary stem cells is available from a variety of sources. Numerous transplantation experiments have shown that isolated segments from any portion of the developing or even lactating gland are capable of regenerating a complete mammary ductal and alveolar network (DeOme et al., 1959Go; Hogg et al., 1983Go; Smith and Medina, 1988Go). Perhaps most convincingly, Kordon and Smith showed that an entire mammary gland could be regenerated with the progeny of a single cell following transplantation into cleared mammary fat pads (Kordon and Smith, 1998Go). Additional evidence for the existence of mammary stem cells may be derived from observations that entire mammary lobules are often comprised of cells showing identical X-inactivation patterns, and from cancer studies where mammary tumors comprised of a variety of cell types are frequently found to be of clonal origin (Tsai et al., 1996Go)."
"No genetic marker has yet been found to identify mammary stem cells in situ. However, histological analyses have indicated that a pale staining cell population present during all stages of mammary development and differentiation in mice and rats may serve as mammary stem cells (Chepko and Smith, 1997Go). Such "pale cells" have been described in mammary tissue from all species so far examined, including humans (Ferguson, 1985Go), mice (Smith and Medina, 1988Go), rats (Chepko and Smith, 1997Go), goats (Li et al., 1999Go), and cattle (Ellis et al., 2000Go; Ellis and Capuco, 2002Go)."
Any potential for experimentaion for breast regrowth ?
What are the impacts in terms of cancer mechanisms?
Any thoughts?
RB
http://jas.fass.org/cgi/content/full/81/suppl_3/18
Lactation persistency: Insights from mammary cell proliferation studies
A. V. Capuco*,1, S. E. Ellis§, S. A. Hale¶, E. Long{dagger}, R. A. Erdman¶, X. Zhao# and M. J. Paape
ABSTRACT
"Evidence for the existence of mammary stem cells is available from a variety of sources. Numerous transplantation experiments have shown that isolated segments from any portion of the developing or even lactating gland are capable of regenerating a complete mammary ductal and alveolar network (DeOme et al., 1959Go; Hogg et al., 1983Go; Smith and Medina, 1988Go). Perhaps most convincingly, Kordon and Smith showed that an entire mammary gland could be regenerated with the progeny of a single cell following transplantation into cleared mammary fat pads (Kordon and Smith, 1998Go). Additional evidence for the existence of mammary stem cells may be derived from observations that entire mammary lobules are often comprised of cells showing identical X-inactivation patterns, and from cancer studies where mammary tumors comprised of a variety of cell types are frequently found to be of clonal origin (Tsai et al., 1996Go)."
"No genetic marker has yet been found to identify mammary stem cells in situ. However, histological analyses have indicated that a pale staining cell population present during all stages of mammary development and differentiation in mice and rats may serve as mammary stem cells (Chepko and Smith, 1997Go). Such "pale cells" have been described in mammary tissue from all species so far examined, including humans (Ferguson, 1985Go), mice (Smith and Medina, 1988Go), rats (Chepko and Smith, 1997Go), goats (Li et al., 1999Go), and cattle (Ellis et al., 2000Go; Ellis and Capuco, 2002Go)."