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View Full Version : inflammation contributes to progression of benign to malignant breast lesions--NSAIDS


Lani
03-21-2006, 06:26 PM
may help prevent

Inflammation contributes to breast disease progression
Inflammation may help mediate the progression from benign to malignant breast disease, US researchers have discovered.

Recognizing that benign breast disease (BBD) is a risk factor for developing breast carcinoma, the team examined for factors predicting this progression among 1467 women who were diagnosed with BBD in 1989, 91 of whom were subsequently diagnosed with breast cancer by 2003.

In particular, data on the patients' medication use between 1989 and 1996 were collated, and the women's cyclo-oxygenase (COX) genotypes were determined.

Analysis showed that participants who had used aspirin in 1989 and in 1996 were significantly less likely to have been diagnosed with malignancy than those who had not, with odds ratios (OR)s of 0.46 and 0.47, respectively. For use of any nonsteroidal anti-inflammatory drug (NSAID), including aspirin, the corresponding risks were 0.60 and 0.64.

Indeed, the risk of developing breast cancer fell with increasing frequency, dose, and duration of aspirin use in the women, Kathy Helzlsouer (Mercy Medical Center, Baltimore, Maryland) and co-workers say.

The scientists failed to find an overall link between COX genotype and breast cancer risk. However, homozygous carriers of the rs2143416 polymorphism who were not taking NSAIDs had a significant five-fold increased risk of the disease compared with women taking NSAIDs who had one or no rs2143416 alleles.

"The results of the current study suggest that inflammation, especially in relation to the COX-2 pathway, may play a role in the progression of BBD to breast carcinoma, and that this may be modified by the use of NSAIDs, particularly aspirin," the authors summarize.

Noting that not all women with BBD proceed to breast cancer, they conclude: "Finding ways to tailor primary and secondary prevention interventions, perhaps on the basis of genetic profiles, may assist in reducing the risk of breast carcinoma while minimizing exposure to the untoward effects of chemopreventive agents."



Cancer 2006; 106: 1443–1552

Unregistered
03-22-2006, 04:09 AM
Thanks Lani interesting. - Links to fats omega six - Links to curcumin etc natural "NASIDS".

Interesting it is asprin. From slightly hazy memory I have read the asprin acts on the series two pathways COX 2 LOX etc but not the series three etc, but that some NASIDS do, which I suppose is of relevance as the series three products moderate inflamation.

RB