Bev
03-10-2006, 08:59 PM
Gene Expression Superior to Histology for Breast Cancer Prognosis
NEW YORK FEB 27, 2006 (Reuters Health) - Gene (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Gene%27,%27Glossary%27,%27dependent =yes,alwaysRaised=yes,scrollbars=yes,resizable=yes ,width=400,height=250,titlebar=yes,screenX=300,scr eenY=200,left=300,top=200%27%29) expression profile appears to be much more accurate than tissue grade in making a prognosis in women with histology (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=histology%27,%27Glossary%27,%27depe ndent=yes,alwaysRaised=yes,scrollbars=yes,resizabl e=yes,width=400,height=250,titlebar=yes,screenX=30 0,screenY=200,left=300,top=200%27%29) grade 2 breast cancers, researchers report in the February 15th issue of the Journal of the National Institute of Cancer.
Dr. Christos Sotiriou and colleagues at the Jules Bordet Institute in Brussels, Belgium, collected data from 189 invasive breast carcinomas, using three gene (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Gene%27,%27Glossary%27,%27dependent =yes,alwaysRaised=yes,scrollbars=yes,resizable=yes ,width=400,height=250,titlebar=yes,screenX=300,scr eenY=200,left=300,top=200%27%29) expression datasets to assess whether histologic grade was associated with gene expression profile.
The researchers identified 64 estrogen (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Estrogen%27,%27Glossary%27,%27depen dent=yes,alwaysRaised=yes,scrollbars=yes,resizable =yes,width=400,height=250,titlebar=yes,screenX=300 ,screenY=200,left=300,top=200%27%29) receptor-positive tumor samples. They then devised a gene expression grade index by comparing gene expression profiles of histologic grades 1 and 3 tumors with the gene expression datasets.
Using the index, Dr. Sotiriou's team assessed data from 597 independent tumors (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Tumor%27,%27Glossary%27,%27dependen t=yes,alwaysRaised=yes,scrollbars=yes,resizable=ye s,width=400,height=250,titlebar=yes,screenX=300,sc reenY=200,left=300,top=200%27%29) to evaluate relapse-free survival time. They identified 97 genes that were associated with histologic grade. Most were involved in cell (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Cell%27,%27Glossary%27,%27dependent =yes,alwaysRaised=yes,scrollbars=yes,resizable=yes ,width=400,height=250,titlebar=yes,screenX=300,scr eenY=200,left=300,top=200%27%29) cycle regulation and proliferation.
Gene expression profiling was strongly associated with histologic grades 1 and 3 status, but histologic grade 2 tumors "spanned the values" of the index. For those patients, "a high gene expression index was associated with a higher risk of recurrence than a low gene expression index," carrying a hazard ratio of 3.61.
The authors conclude that "relapse-free survival was more strongly associated with gene expression grade than histology (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=histology%27,%27Glossary%27,%27depe ndent=yes,alwaysRaised=yes,scrollbars=yes,resizabl e=yes,width=400,height=250,titlebar=yes,screenX=30 0,screenY=200,left=300,top=200%27%29) grade." In addition, the gene expression index "appears to reclassify patients with histology grade 2 tumors into two groups, with high versus low risk of recurrence."
NEW YORK FEB 27, 2006 (Reuters Health) - Gene (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Gene%27,%27Glossary%27,%27dependent =yes,alwaysRaised=yes,scrollbars=yes,resizable=yes ,width=400,height=250,titlebar=yes,screenX=300,scr eenY=200,left=300,top=200%27%29) expression profile appears to be much more accurate than tissue grade in making a prognosis in women with histology (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=histology%27,%27Glossary%27,%27depe ndent=yes,alwaysRaised=yes,scrollbars=yes,resizabl e=yes,width=400,height=250,titlebar=yes,screenX=30 0,screenY=200,left=300,top=200%27%29) grade 2 breast cancers, researchers report in the February 15th issue of the Journal of the National Institute of Cancer.
Dr. Christos Sotiriou and colleagues at the Jules Bordet Institute in Brussels, Belgium, collected data from 189 invasive breast carcinomas, using three gene (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Gene%27,%27Glossary%27,%27dependent =yes,alwaysRaised=yes,scrollbars=yes,resizable=yes ,width=400,height=250,titlebar=yes,screenX=300,scr eenY=200,left=300,top=200%27%29) expression datasets to assess whether histologic grade was associated with gene expression profile.
The researchers identified 64 estrogen (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Estrogen%27,%27Glossary%27,%27depen dent=yes,alwaysRaised=yes,scrollbars=yes,resizable =yes,width=400,height=250,titlebar=yes,screenX=300 ,screenY=200,left=300,top=200%27%29) receptor-positive tumor samples. They then devised a gene expression grade index by comparing gene expression profiles of histologic grades 1 and 3 tumors with the gene expression datasets.
Using the index, Dr. Sotiriou's team assessed data from 597 independent tumors (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Tumor%27,%27Glossary%27,%27dependen t=yes,alwaysRaised=yes,scrollbars=yes,resizable=ye s,width=400,height=250,titlebar=yes,screenX=300,sc reenY=200,left=300,top=200%27%29) to evaluate relapse-free survival time. They identified 97 genes that were associated with histologic grade. Most were involved in cell (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=Cell%27,%27Glossary%27,%27dependent =yes,alwaysRaised=yes,scrollbars=yes,resizable=yes ,width=400,height=250,titlebar=yes,screenX=300,scr eenY=200,left=300,top=200%27%29) cycle regulation and proliferation.
Gene expression profiling was strongly associated with histologic grades 1 and 3 status, but histologic grade 2 tumors "spanned the values" of the index. For those patients, "a high gene expression index was associated with a higher risk of recurrence than a low gene expression index," carrying a hazard ratio of 3.61.
The authors conclude that "relapse-free survival was more strongly associated with gene expression grade than histology (http://javascript%3Cb%3E%3C/b%3E:OpenPopupWin%28%27/glossary/popup.asp?term=histology%27,%27Glossary%27,%27depe ndent=yes,alwaysRaised=yes,scrollbars=yes,resizabl e=yes,width=400,height=250,titlebar=yes,screenX=30 0,screenY=200,left=300,top=200%27%29) grade." In addition, the gene expression index "appears to reclassify patients with histology grade 2 tumors into two groups, with high versus low risk of recurrence."