IBC Medullary,Mucinous Carcinoma

[Lyn]

Hi all, seems this is a type of IBC,Medullary Carcinoma and Mucinous Carcinoma, as well as referred to as IDCI, very confusing, just wondering how it differs in appearence to regular IBC, wishful thinking apperently it is not as agressive.

Love & Hugs Lyn

[Kristen]

Lyn, I am so sorry to hear. I looked up your situation in at the National Library of Medicine at PubMed and you are certainly rare. A lot of the information came up with this in the ovaries and colon and lung. So I redid the search and put in IBC Medullary Carcinoma and got no hits and then put in Mucinous Carcinoma and found some, I am attaching one article, but I wish I had more time to look up more stuff for you. If you go to that site, you will understand how rare this is and will understand how hard it is to detect. I guess that is why it took so long for them to figure it out. Your like a cat and have so many more lives to live and you will get through this also. It just stinks tha t you had to get this. LOL k I hope I got the correct abstract, since they call it different names than what was posted.
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1: Cancer. 2004 Sep 1;101(5):905-12. Related Articles, Links


Clinicopathologic characteristics of 143 patients with synchronous bilateral invasive breast carcinomas treated in a single institution.

Intra M, Rotmensz N, Viale G, Mariani L, Bonanni B, Mastropasqua MG, Galimberti V, Gennari R, Veronesi P, Colleoni M, Tousimis E, Galli A, Goldhirsch A, Veronesi U.

Division of Breast Surgery, European Institute of Oncology, Milan, Italy. mattia.intra@ieo.it

BACKGROUND: Synchronous bilateral invasive breast carcinoma (SBIBC) ranged in incidence from 0.3% to as high as 12%. METHODS: Between April 1997 and February 2003, 143 consecutive patients with SBIBC were treated at the European Institute of Oncology (Milan, Italy). Their information was collected prospectively in a database. The bilateral tumors were divded into left and right tumors. Tumor size, histology, grade, lymph node status, estrogen (ER) and progesterone receptor (PgR) status, HER-2 expression, peritumoral vascular invasion (PVI), Ki-67 expression, extensive in situ component (EIC), and multifocality between the two groups were analyzed. During the same time period, 6218 patients with unilateral invasive breast carcinoma (UIBC) were analyzed in the same manner for comparison with the patients with SBIBC. RESULTS: There were no significant differences between left and right tumors, and the observed histopathologic agreement within the same patient was significantly superior than statistically expected for all characteristics except size, lymph node status, and multifocality. When compared with patients with UIBC, patients with SBIBC were more likely to present with smaller tumors and showed a higher frequency of invasive lobular carcinoma, lower histologic grade, higher rate of ER and PgR positivity, and lower PVI and Ki-67 expression. CONCLUSIONS: The high concordance of histopathologic characteristics between SBIBC within the same patient could reflect a particular hormonal environment that influenced either the initiation and development of these lesions simultaneously and independently from the single or multi-clonal origin, either a less aggressive biological behavior compared with UIBC. In particular, the strong agreement of the observed EIC in SBIBC within the same patient seemed to definitively exclude the metastatic origin of these tumors. Copyright 2004 American Cancer Society

[Lolly]

Lyn, my primary bc back in 1999 was dx as infiltrating ductal carcinoma, mucinous type, but "with poor nuclear grade(III) and poorly differentiated"; the research I found indicated that mucinous type tumors are less aggressive, but I also had the other aggressive factors including er/pr- and her2+. But I wonder if that's a reason why it hasn't spread outside of my lymph nodes yet...
Anyway, here's a bit of info I copied onto my pathology report:

"...Mucinous (Colloid) Carcinoma - a rare variant type of cancer that is associated with a better prognosis. This tumor is associated with extensive extracellular mucin production, usually occur in older women, and grow with a smooth pushing border. Over 90% of the tumor should be associated with extracellular mucin, and over 30% of the area of the tumor should be mucin, not tumor cells. These tumors also have a low-grade nuclei..."

I don't know if this helps or not, but hope so. Still looking for research on the Herceptin, Carboplatin, Xeloda combo with radiation, but so far just that Herceptin and Carbo are synergistic and Herceptin and Xeloda are additive, so you may be breaking new ground again! Will keep looking and in the meantime chin up :)

Love, Lolly

[Lyn]

Hi Lolly, I got out my original histology and although it was thorough it did not mention Mucinous & Medullary Carcinomas but I have e-mailed you with a report it is a bit long but worth reading because it covers other questions as well and it is very interesting and looks like may have pinpointed my BC and at least it is favourable. I e-mailed Sandy as well we may have our own disease? Saw rads Onc today and he isn't in favour of any surgery for me because I am unchartered waters so to speak. I am still digging.

Love & Hugs Lyn