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ThioplexGeneric name: Thiophosphoamide
Trade name: Thioplex
Other names: Thiotepa
Drug type: Thiotepa is a chemotherapy drug used to treat breast cancer, ovarian cancer, bladder cancer, Hodgkin's lymphoma and, rarely, high grade non Hodgkin's lymphoma. It is one of a group of drugs called alkylating agents. These work by sticking to one of the cancer cell's DNA strands. The cell cannot then divide into 2 new cells.
How you have treatment
Thiotepa is a clear liquid that you can have in a number of different ways
You usually have chemotherapy as a course of several cycles of treatment. The treatment plan for thiotepa depends on which type of cancer you have. There is detailed information about how doctors plan chemotherapy in CancerHelp UK.
Thiotepa side effects are listed below. You can use the links to find out more about each side effect or click on search at the top of the page.
Common side effects
Many people experience a temporary drop in the number of blood cells made by your bone marrow, leading to the following side effects
Other common side effects include
Occasional side effects
Some people may have one or more of the following side effects
Rare side effects
A small number of people may have one or more of the following side effects
Side effects of high dose thiotepa
With high dose thiotepa before a bone marrow or stem cell transplant, you may have
Important points to remember
The side effects above may be mild or more severe. A side effect may get better or worse through your course of treatment, or more side effects may develop as the course goes on. This depends on
Some side effects are inconvenient or upsetting but not damaging to your health.
Some side effects are serious medical conditions and need treating. Where we have urged you to contact your doctor, this is because
Tell your doctor about any other medicines you are taking, including vitamins, herbal supplements and other over the counter remedies – some drugs can react together. Talk to your doctor, pharmacist or nurse about all your side effects so that they can help you manage them. Your chemotherapy nurse, clinic or ward nurse will give you a contact number. You can ring if you have any questions or problems. They can give you advice or reassure you. If in doubt, call them.
Immunisations and chemotherapy
You should not have immunisations with live vaccines while you are having chemotherapy or for at least 6 months afterwards. In the UK, these include rubella, mumps, measles (usually given together as MMR), BCG and yellow fever. You can have other vaccines, but they may not give you as much protection as usual until your immune system has fully recovered from your chemotherapy.
It is perfectly safe for you to be in contact with other people who've had live vaccines as injections. There can be problems with oral vaccines, but no one in the UK is given an oral vaccine now. So there is no problem in being with any baby or child who has recently had any vaccination in the UK. If you live abroad, you might need to make sure that you aren't in contact with anyone who has had oral polio or oral typhoid vaccination recently.
|Last Updated on Thursday, 21 January 2010 10:00|